Androgen deprivation therapy (ADT) administered though surgical or medical castration is currently the standard treatment for men with locally advanced or metastatic prostate cancer. This review paper addresses this knowledge gap by discussing PC disparity associated with nutritional factors and highlighting the biomedical significance of three medicinal plants (curcumin, garlic, and Vernonia amygdalina) that show a great potential to prevent/treat PC, as well as to reduce its incidence/prevalence and mortality, improve survival rate, and reduce PC-related health disparity.Īndrogens play a crucial role in the differentiation, development, and normal functioning of prostate and, therefore, androgens may have an important role in developing prostate carcinogenesis. In addition, there are limited studies that have addressed the benefits of medicinal plants as chemo-preventive agents for PC treatment, especially among AA men.
However, its mortality rate remains significantly high among AA men.
Our search results revealed that there are significant improvements in PC statistics among white men and other ethnic groups. To reach this central goal, we searched the PubMed Central database and the Google Scholar website for relevant papers. Hence, the central goal of this article is to highlight PC disparity associated with nutritional factors and highlight chemo-preventive agents from medicinal plants that are more likely to reduce PC. As such, this population group may benefit from edible natural products that are safe with a low cost. Despite advances in screening for and early detection of PC, a large percentage of men continue to be diagnosed with metastatic disease including about 20% of men affected with a high mortality rate within the African American population. The treatment decisions for PC are based exclusively on histological architecture, prostate-specific antigen (PSA) levels, and local disease state.
Its incidence and mortality rates are higher in African American (AA) men compared to white men and other ethnic groups. The global burden of this disease is rising. Prostate cancer (PC) is one of the most common cancers in men.
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